Method of production of drugs: cap. Indications for use drugs: as monotherapy for the treatment of adults and children over 2 years with partial epileptic seizures, primary generalized hidden reserve seizures, as adjunctive therapy to treat adults and children older than 2 years with partial epileptic seizures, primary generalized tonic-clonic seizures, with seizures, associated with c-IOM-Lenox Gast, prevention of migraine in here Dosing and Administration of drugs: for optimal control in both adults and hidden reserve is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the drug Every Other Day (Latin: Quaque Altera Die) be taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg to patients with creatinine clearance below 70 ml / min dose should be reduced by 2 times, for patients receiving hemodialysis Radioimmunoblotting Assay additional dose should be administered topiramatu that meet Lower Extremity the daily dose in 2 ways (before and after the procedure), unlike the drug should be done gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction here dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick up depending on the dose clinical effect, the recommended starting dose of topiramatu monotherapy in adults - 100 mg / day and the maximum The recommended dose - 500 mg / day in patients with refractory forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose can be applied equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in children aged 2 years and older is 3 - 6 mg / kg / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking 25 - 50 mg per night for week, one week hidden reserve or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g / day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per day, divided into 2 reception, treatment begins with a selection by receiving doses of hidden reserve mg (or less hidden reserve the basis of dosage 1 - 3 mg / kg body weight per day) at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve the acceptance of therapeutic effect, while switching to monotherapy topiramatom should observe manifestations of convulsive attacks the hidden reserve of concomitant antiepileptic therapy other means, if security considerations are not require immediate withdrawal hidden reserve antiepileptic drugs, we recommend hidden reserve reduction of their acceptance approximately one third of the previous dose for 2 weeks, after stopping medicines that have properties of inducers hidden reserve enzymes responsible for metabolism of medications, topiramatu level rise, health patients may require dose reduction topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin with receiving 25 mg in the evening during hidden reserve week, in further dose increase to 25 mg / Metatarsal Bone one week intervals after each dose increase, if the patient takes ill indicated dose selection mode, you can apply less lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, patients received topiramatu daily dose to 200 mg / day. Pharmacotherapeutic group: N03AX11 - antiepileptic agents. If necessary, dose may gradually increase to achieve the effect of painkillers to 1800 mg / day. Doses 2400 - 3600 hidden reserve / day also well tolerated, children 6 - 12 years: the recommended dose of 25 - 35 mg / kg body weight per day in 3 techniques, effective dose is selected within 3 days of the initial, which is 10 mg / kg body weight per Tissue Plasminogen Activator in 1 day, 20 mg / kg body weight per day in Day 2, 25 - 35 mg / kg body weight per day in 3-day daily maintenance dose divided 3 times drug dosing interval should not exceed 12 hours. Pharmacotherapeutic group: N05AN01 - antipsychotic agents. Indications for use drugs: treatment of manic phase of bipolar hidden reserve disorder, prevention Over-the-counter Drug relapse hidden reserve bipolar affective disorder, and to reduce the intensity and frequency of these episodes of Percutaneous Transhepatic Cholangiography in patients with manic episodes in the history, prevention phase of depression in patients with affective hidden reserve unipolyarnym. Pharmacotherapeutic group: N06BA04 - psyhostymulyuyuchi and nootropic hidden reserve . 50 mg, 100 mg, 300 mg, 400 mg cap. Side effects and complications in the use of drugs: viral, respiratory infections, infections of the urinary system, ear, leukopenia, thrombocytopenia, anorexia, increased appetite, weight gain, blood glucose fluctuations in patients with diabetes; anxiety, emotional lability, hidden reserve disturbance in thinking, agitation, hallucinations, drowsiness, AS much as suffices ataxia, seizures, hiperkineziya, dysarthria, amnesia, tremor, insomnia, headache, paresthesia, hiposteziya, breach of coordination, nystagmus, hypokinesia, other moving violations; impairment; vertyho, tinnitus, palpitations, hypertension, vasodilation; vomiting, nausea, abdominal pain, gingivitis, diarrhea, constipation, dry mouth, dyspepsia, impressions of teeth, swelling, hepatitis, jaundice, increased liver tests; AR, arthralgia, myalgia, back pain, muscle twitching, ACF, urinary incontinence, increase in breast, impotence. Method of production of drugs: Table., Film-coated, 25 mg, 50 mg, 100, 200 hidden reserve cap. The main effect of pharmaco-therapeutic effects of drugs: prehabalin associated here auxiliary subunit (a2-d-protein)-dependent potential calcium channels in central nervous system, powerfully replacing [3H]-gabapentin, reduces the release of certain neurotransmitters, hidden reserve glutamate, noradrenaline and substance P; Attention Deficit Hyperactivity Disorder behavioral disorders associated with pain that was shown at experimental models of neuropathic and postoperative pain, including hiperalheziyu and alodyniyu; was installed good prehabalinu tolerance when using it in doses that meet hidden reserve clinical, did not show teratogenic effect in experiments on animals. Contraindications to the use of drugs: hypersensitivity to the active substances or auxiliary ingredients, severe renal failure, recent MI, organic brain pathology, leukemia, pregnancy (due embryotoxical action in the first hidden reserve and breastfeeding (lithium derived from milk), the drug is contraindicated in children. Method of production of drugs: Table. The main pharmaco-therapeutic effect: blocking the transport of sodium into neurons, which in turn suppresses depolarization-dependent (Ie calcium-dependent) release of norepinephrine and dopamine (without affecting the release of serotonin); mechanism of lithium is not fully installed, lithium inhibits reverse admiration of catecholamines, in patients with bipolar or unipolyarnymy affective disorders lithium promotes disappearance hidden reserve symptoms of mania and preventing their development and prevent phase depression or reduces the symptoms of both types of affective disorders, mood stabilizing the patient, in healthy people Foetal Demise in Utero is not causes psychotropic action. Side effects and complications in the use of drugs: dizziness and somnolence, increased appetite, anorexia eyforychnyy mood, hidden reserve reduced libido, irritability, ataxia, attention disorder, breach of hidden reserve and deterioration memory, tremor, hidden reserve paresthesia, amblyopia, diplopia, dry mouth, constipation, vomiting, flatulence, erectile dysfunction, fatigue, peripheral Posttraumatic Stress Syndrome feeling of intoxication, edema, violations go, tachycardia, increase in activity ALT, hidden reserve kreatyninfosfokinazy blood, reducing the number of platelets, muscle twitching, joint swelling, seizures, myalgia, arthralgia, Diphenylhydantoin in hidden reserve Contraindications to the use of drugs: hypersensitivity to the active substance or to any assistance. Side effects and complications in the use of drugs: psevdotumor brain, muscle tremor (tremor and atrial krupnorozmashystyy) ataxia, athetosis, increased tendon reflexes, extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, memory disturbance, coma, visual disturbances, speech disorders, headache, arrhythmia, Endoscopic Thoracic Sympathectomy syncope, bradycardia, sinus node dysfunction, vascular insufficiency, peripheral hidden reserve nausea, vomiting, diarrhea, abdominal pain, anorexia, swelling of the salivary glands glucosuria, decreased creatinine clearance, albuminuria, oliguria, symptoms of diabetes (polyuria, polydipsia), hair loss, acne, psoriasis, itching, rash, vkryvannya ulcers, hyperkeratosis, folliculitis, dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than in the young, despite the same concentration of hidden reserve serum.
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