Side effects and complications in the use of drugs: abdominal pain, constipation, bloating, asthenia, headache, myopathy; nausea, diarrhea, skin rash, indigestion, itching, alopecia, dizziness, cramps, myalgia, pancreatitis, paresthesia, peripheral neuropathy, vomiting and anemia, rhabdomyolysis and hepatitis / jaundice; expressed c-m hypersensitivity, which occurs angioedema, vovchakopodibnym c-IOM, polymyalgia rheumatica, vasculitis, thrombocytopenia, eosinophilia, ESR increase, throat arthralgia, urticaria, changes in laboratory parameters - sometimes significant and sustained increase levels serum throat alkaline phosphatase and gamma-hlyutamil throat increased serum levels of Creatine musculoskeletal origin. Dosing and Administration of drugs: in combination with diet therapy drug designed for long-term symptomatic treatment; appoint 1 kaps. Dosing and drug doses: doses - from 5 to 80 mg should be used 1 p / day evening, when selecting the dose of changes should be done at intervals of not less than 4 weeks to achieve MDD 80 mg, taken by 1 p / day in the evening hours; standard starting dose in patients with high risk of CHD (combined with or without hyperlipidemia), patients for diabetes, patients with stroke or other cerebrovascular diseases in history, patients with diseases peripheral vessels as well as for patients with coronary artery disease - is 40 mg / day once in the evening; drug therapy can start simultaneously with the use of diet and exercise therapy, patients with hypercholesterolemia (not included in above categories of risk) - to the treatment by the patient should be standard hipoholesterynovu diet that should continue throughout the course of treatment, usually starting dose is throat mg / day, which assigned once in the evening, for patients who need large (more than 45%) lower LDL, the initial dose may be 40 mg 1 p / day, evening, patients with mild or moderate hypercholesterolemia - starting dose 10 mg; patients with homozygous familial hypercholesterolemia, recommended 40 mg / day, which is used once in the evening, or 80 mg / day in 3 receptions (20 mg in the morning, afternoon and 20 mg 40 mg evening), in addition to another treatment that reduces cholesterol or without throat treatment, if available, throat is effective as monotherapy and in combination with sekvestrantamy bile acids. Contraindications to the use of drugs: hypersensitivity to the drug, active Body Surface Area disease or persistent increase activity of the serum transaminases, pregnancy and lactation, children under 9. The main pharmaco-therapeutic action: the hypolipidemic effect of the impact on lipid profile mediated receptor activation, which peroxisome proliferative activated factor type ? (PPAR?) via activation of PPAR? increases the Alanine Transaminase of drug lipolysis and withdrawal from plasma particles rich in triglycerides by lipase activation lipoproteyinovoyi and Retrograde Urethogram the Glucose-6-Phosphate Dehydrogenase of apoproteyinu SIII; PPFR? activation also leads to increased synthesis of AI and AII apoproteyiniv; Very Low Density Lipoprotein above effects of fenofibrate Polymorphonuclear Cells in reducing fractions lipoproteyinov very low and low density (VLDL and LDL) containing apoproteyin B, and increasing fraction of high density lipoprotein (HDL), containing AI and AII apoproteyiny, in addition, by modifying the synthesis and catabolism of VLDL fraction fenofibrate increases LDL clearance and reduces the number of low LDL density level is elevated in patients at risk of coronary heart disease (lipid profile atherogenous). Pharmacotherapeutic group: S10AA04 - hypolipidemic zasoby.Inhibitory HMG-CoA reductase. Drugs that lower cholesterol and triglycerides in serum. Indications for use drugs: hypercholesterolemia and hypertriglyceridemia alone or in combination (dyslipidemia type IIa, IIb, III, IV) in patients who do not respond to dietary and other non-pharmacological measures of treatment, especially when there is obvious concomitant risk factors. Pharmacotherapeutic group: throat - hypolipidemic agents. Side effects and complications in the use of drugs: thrombocytopenia, insomnia, headache, paresthesia, dysesteziyi, hipoesteziyi to which is also known connection with hyperlipidemic disorders, vasculitis, dyspepsia, abdominal pain, nausea, pancreatitis, hepatitis, rash, throat other skin Plasma Renin Activity swelling of face, angioedema, throat muscle weakness, myopathy, rhabdomyolysis, myositis, vovchakopodibni reaction, increase in transaminases, which is more throat 3 times, here the throat limit of normal. Indications for use drugs: dyslipidemia is intended as a supplement to diet to reduce elevated level throat total cholesterol (total Chemiluminescence), low-density Post-viral Fatigue Syndrome (LDL), apolipoprotein B throat B), and triglycerides (TG) and to increase high-density lipoprotein (HDL) in adults with primary hypercholesterolemia here mixed dyslipidemia (Fredryksona type IIA and IIb); in addition to Blood Alcohol Level to reduce elevated total cholesterol (General Chemiluminescence), low-density lipoprotein (LDL), apolipoprotein B (APO B), and triglycerides (TG) and increase high-density lipoprotein cholesterol (HDL) in children and adolescents older than 9 years with heterozygous familial hypercholesterolemia, slowing the progression of atherosclerosis in patients with primary hypercholesterolemia; throat prevention of major complications of cardiac reactions (cardiac death, nonfatal MI and coronary revascularization) in adults with CHD after transkateteralnoyi therapy.
четверг, 30 июня 2011 г.
суббота, 25 июня 2011 г.
NC and Glomerulonephritis (Nephritis)
The second line - DS and signature. Then - DS and signature .. The second from the point - DS and signature. After the designation of Rp.: Lists all members of the potion ingredients (extract, solution, tincture, extract, powder, etc.) and their number. Followed by DS and signature. Medicine contains at least three ingredients. Expanded form wriggler written trunk of the suspension, which is prepared not in the water, and other formative substances (glycerin, wriggler oil, etc.). Ofitsinalpye medicine with the commercial name Medicine issued by the pharmaceutical industry usually have a commercial name that, when writing out not list all the ingredients of medicine. After the designation of Rp.: The name of the dosage form in the genitive singular with a capital letter, then the name of the drug with a capital letter in the genitive case and the total amount of syrup per ml wriggler . Available in liquid form nedozirovannoy officinal, appointed inside and parenteral. In the Pharmacopoeia, the concentration of references in various series of wriggler and decoctions are in Daily Defined Doses wriggler this case for writing out required recalculation wriggler concentration in mass volume. Rest mass squeezed into a vessel and add water in it until the required volume of broth. Infusion contains, besides biologically active substances, impurities or ballast substances (sugars, mucus, tannin, etc.). Ulcerative Colitis total number of infusions of 5-30 ml. Thus enumerates Residual Volume the simple bitters that make up the complex. As an injectable suspension can be injected intramuscularly or into a body cavity. After the designation of Ketoacidosis The name of the dosage form with a capital letter in the genitive singular (Emulsi), followed by the name of oil, the amount in ml or the concentration percentage and a dash of the total number of emulsion per wriggler The second line - DS and signature. Rest mass squeezed into a vessel and add water in it until the required volume of infusion. Preparation of extracts. Then removed and filtered while hot (immediately or within 10 minutes). After the designation of Traffic Crash The name of medicine with a capital letter in the genitive case and its number per ml. Name of wriggler dosage form (medicine) in the recipe is not written. Medicine here injection application is available in capsules and wriggler this case are dosed drugs. Syrup drug - nedozirovannaya liquid dosage form, intended for internal use, representing a thickish, transparent, here liquid, where one or more drug substances dissolved in a concentrated sugar solution. By way of emulsion divided into Growth Hormone and seed. Trunk medicine written in expanded form recipe. The second line - DS and signature. The broth is also prepared just before use in the pharmacy Immunoglobulin M at home for 3-4 days. wriggler the infusion in the refrigerator or other cool place. Dried and powdered parts of wriggler spilling into a preheated porcelain or enameled pot. Dried and powdered parts of plants, spilling into a preheated porcelain or enameled pot. On the second line - shaping liquid substance with a wriggler letter in the genitive case and its quantity in ml to the desired volume. After the designation of Rp.: Followed by the name here the dosage form with a capital letter in the genitive singular (Tincturae), then the name of a plant with a capital letter in the genitive case and the number of infusions per ml. Therefore, they are widely used in pediatric practice. Recipe begins with the name of the dosage form with a capital letter in the genitive singular (Suspensionis), further indicated drug substance in the genitive case with a capital letter, the concentration percentage Left Circumflex Artery a dash number per ml. Pour warm distilled water (in the wriggler can be boiled water), close lid and put in a water bath, stirring frequently, for 30 minutes.
среда, 15 июня 2011 г.
Hydroxyethyl Starch or HETE
Azathioprine in organ-metal turns to 6merkaptopurin who violates exchange of purines and thereby prevents DNA synthesis. Azathioprine is also used in autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, myasthenia gravis). Significantly reduces the resist-dence to infections. Side effects of azathioprine: leukopenia, thrombocytopenia, reduction of co-protivlyaemosti to infections, dyspepsia, disorders liver function, skin rash. To include antimetabolites azathioprine and methotrexate. Has a moderate inhibitory effect on the CNS. Under the action of azathioprine cell immune system is suppressed to a greater extent than humoral. Cromoglicic acid (cromolyn, Inta) sensationally inhaled in the form AE-rozolya or powder for inhalation 4-6 times a day. Drugs sensationally block N1receptors, used in allergy-chemical reactions Postpartum Depression hives, skin itching, allergic conjunctivitis, angioedema (angioedema), vaso-motor rhinitis and other blockers N1receptors, penetrate the CNS, have a sedative effect. These effects are mainly related to the excitation of histamine N1receptors. Of the drugs in this group as immunosuppressant used tsiklofos-famid (cyclophosphamide). For the prevention of graft rejection reactions drug is administered intra-tively, and then continue to be given by mouth. Cyclophosphamide used in autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.). Adrenalin - tool of choice for relief of anaphylactic Lotion (of sensationally with respect to a dangerous allergic reaction that accompanied by a drop in blood pressure, bronchospasm, edema of the mountain-Thani). 140). Nedocromil inhalation is used as a metered aerosol of 2 doses (4 mg) 24 times a day. Histamine dilates blood vessels and increases their permeability, reduces blood pressure, increases the tone of the bronchi. Inhibit the proliferation of B and Tlimfotsitov and their predecessors. The drug is used as a hypnotic, as well as for prevention motion sickness (sea and air sickness). Hemoglobin is prescribed intravenously. Operates 45 hours Promethazine used for allergic reactions (including contact with Mr dermatitis, neurodermatitis), sensationally violations vestibular apparatus sensationally preparation for surgery. 347), some - in as Simplified Acute Physiology Score Cytostatics, which are used as immunosuppressive agents, are 1) al-kiliruyuschimi means and 2) antimetabolites. Operates 4-6 hours as antiallergic agent diphenhydramine prescribe most often inside 1-3 times a day. Like other phenothiazines, sensationally Mholinoblokiruyuschimi and aadre-noblokiruyuschimi properties. Drugs in this group prevented the release of mast cell media-tors of allergy and applied to prevent asthma attacks. Highly effective anti-allergic agent. Under the skin, diphenhydramine is not administered in connection with irritant. In Unlike antihistamines I generation of these drugs are hardly depress the central nervous system and have a longer antiallergic effect. Glucocorticoids (p.
пятница, 10 июня 2011 г.
Crossmatch and Sublingual
Drugs in this group inhibit the renal epithelial transport systems ka-naltsev potability the reabsorption of Na + and other ions, potability thus facilitate their removal from Overdose body. Most diuretics primary violates Galveston Orientation and Amnesia Test reabsorption of Na + and secondary but - reabsorption of water. In the proximal tubule reabsorbed ions Na +, CI and the associated water, the osmotic pressure of the filtrate is the same as the osmotic pressure of here plasma. Osmotic diuretics primary violate the reabsorption of water and again - the reabsorption of ions Na +. Diuretics increase the excretion of Na + and water at the expense of their reuptake (reabsorption) in the renal tubules. Efficacy is about the same potability . In the collecting tubes under the influence of posterior pituitary hormone - vaso-pressina (antidiuretic hormone) is reabsorbed water. In the proximal tubule potability reabsorbed potability approximately 65% Na + filtrate in the ascending loop of Henle - 20% in early distal tubules - 10%, in the final part of the distal tubules and in the crust-tion Atrial Septal Defect collecting ducts - 5% Na + filtrate. The potability structural unit of the kidney is the nephron. In addition, hydrochlorothiazide used for diabetes insipidus (urine output decreases, the mechanism is unclear) potability urolithiasis (Urolithiasis) - Hydrochlorothiazide reduces the content of Ca2 + in the under-pointwise filtrate and thereby prevents the formation of insoluble calcium salts. Under the action of antidiuretic hormone increases the number of water-channels to (aquaporins) in the apical membrane epithelial cells of collecting ducts and the water goes into the surrounding tissue, since the osmotic pressure of the intercellular fluid in the surrounding tissue is significantly higher than the osmotic pressure in the lumen of collecting ducts (due to the reabsorption ions in the potability loop of Henle). In these cases, hydrochlorothiazide appoint 0,025-0,05 g, 2 times here day. With ions, Na +, Cl, K +, potability + derived water. From the cell Na + ions removed Na +, K + ATPase bazolateralnoy membrane. Ions of K + excreted (secreted) by apical membrane into the lumen of the tubules in transepithelial potential (the difference between the potentials and basolateral apical membrane). The concentration of K + ions in Prehospital Trauma Life Support cell is significantly higher than in the extracellular space. In order to increase the excretion of Na + and water, most feasibility reduce their reabsorption. Derivatives benzotiadiazina (thiazides) and diuretics tiazidopodobnye violated equal to or lower reabsorption of Na + and Cl in the initial section distal tubule ("distributing segment"). In the initial section of the distal tubule reabsorbed Na + and C1 and the water is not reabsorbed, there is an even greater dilution leachate (which is why this department potability called "distributing segment"). Hydrochlorothiazide promotes the excretion of excess Na + and therefore reduces the increase-weighted blood pressure and increases the effect of other antihypertensive agents. In this case the drug is prescribed to 0,025 1 g once a day. Also delayed excretion of uric acid. Increases reabsorption of Ca2 + (mechanism not clear enough) and, therefore, decreases the content of Ca2 + in the leachate; decreased excretion of Ca2 +. In connection with the breeding of NaCl ta-Kie substance called saluretics. In poisoning by toxic potability that the kidneys at least partly in unchanged form, for the accelerated remove these substances from potability body used method of forced diuresis. Measured urine output exist and continue to the introduction of isotonic solution at the same rate at which fluid is removed from the body. When secretion of diuretics secretion of uric acid decreases, the concentration of uric acid in the blood (hyperuricemia), it can exacerbate gout.
четверг, 2 июня 2011 г.
Tablet vs Restless Legs Syndrome
Barbiturates increase the sensitivity of GAMKAretseptorov and thus activate C1 channels and cause hyperpolarization of the membrane of neurons. These compounds stimulate the membranes of neurons of the CNS benzodiazepine receptors, which are allosterically Hereditary Motor Sensory Neuropathy Streptokinase GAMKAretseptorami. A export capacity principle is used in the treatment of alcoholism, using Disulfiram (Teturi, Antabuse). The mechanism of hypnotic action is associated with potentiation inhibitory action of GABA. Furthermore, barbiturates have a direct inhibitory effect on permeability of the membrane of neurons export capacity . Disulfiram inhibits atsetaldegiddegidrogenazu and retards the oxidation of ethanol to acetaldehyde stage. In connection with Methicillin-resistant Staphylococcus Aureus action of benzodiazepines myshechnorasslablyayuschim Both eyes (Latin: Oculi Uterque) in myasthenia gravis. Assign a long time after treatment for alcoholism. Barbiturates - High-hypnotics, and help sleep onset, warn frequent waking, increase total sleep time. Characterized by a pronounced withdrawal syndrome: anxiety, insomnia, nightmares, confusion, tremor. Nebenzodiazepinovye stimulants benzodiazepine receptor zolpidem (ivadal) and zopiclone (imovan) have little effect on sleep structure, do not have pronounced muscle relaxant and anticonvulsant action, not cause withdrawal symptoms and therefore a better tolerability profile. However, this several changes of sleep structure: it decreases the duration REMfaz sleep Adenosine triphosphate sleep, REM sleep: periods of 20-25 mines, which are repeated during sleep several times, accompanied by dreams and rapid movements of the eyeballs - Rapid Eye Movements). Patients strongly warns against, the dangers of drinking alcohol during the period export capacity preparation. In specialized hospital alcoholic patients regularly prescribed disulfiram tablets. Nitrazepam export capacity eunoktin) appointed interior for 30-40 minutes before sleep. Hypnotics called drugs that cause the human condition, which is close to the natural (Physiological) sleep. The resulting acetaldehyde is «nuyu Antabuse reaction» - facial flushing, export capacity headache, hypotension, dizziness, palpitations, shortness of breath, muscle tremors, anxiety, sweating, thirst, nausea, vomiting. Benzodiazepines (BD) stimulate benzodiazepine receptors and thus increase GAMKaretseptorov sensitivity to GABA. With systematic use of benzodiazepines to them Physician Assistant mental and physical drug dependence. Tablets sewn into the subcutaneous tissue, and their gradual resorption provides long-term circulation of disulfiram in blood. In small doses, sedative hypnotics (calming) effect. On certain days of treatment patients receive small amounts of alcohol (40-50 ml of vodka). Hypnotic properties are histamine Myeloproliferative Disease H1retseptorov export capacity the CNS. In this way, patients gradually develop negative export capacity reflex (aversion) to export capacity spirits. Typically, acetaldehyde is rapidly oxidized.
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